Diabetogenesis and albumin molecular modifications newer biological insights and clinical implications

includes bibliographic reference and index

PhD; 2022; Centre for nano science and engineering

To address the many unmet scientific needs in diabetes care (pathogenesis pathways, earliest diagnosis, efficient monitoring, safer and better therapies and importantly prevention approaches), our research focussed on: (a) diabetogenesis and biomarkers and (b) albumin molecular modifications. Establishment of the “Samatvam – Indian Institute of Science” prospective longitudinal cohort, supported by a well annotated biobank repository and a robust cloud based electronic medical record platform, provided the foundation for this translational scientific endeavour. Initially, the "IISc - PathShodh" electrochemistry technology based multianalyte point of care device (POC: anuPath) for selected diabetes biomarkers (HbA1c, hemoglobin, serum albumin, urine albumin and urine creatinine) was validated by simultaneous comparison with “gold standard” conventional laboratory assays. Health worker-based community implementation of this “lab – on – palm”, confirmed its utility both for “in-clinic” diabetes care and “remote” health monitoring.