TY  - BOOK
AU  - Indrakumar, Sushma
AU  - Chatterjee, Kaushik advised
TI  - Silk-based biomaterials for wound care and tissue regeneration
U1  - 600 
PY  - 2023///
CY  - Bangalore
PB  - IISc
KW  - Silk protein
KW  - wound healing
KW  - Tissue regeneration
KW  - Biomaterials
N1  - include bibliographic reference and index; PhD; 2023; Materials engineering
N2  - For most individuals, wound healing is a highly organized, straightforward process. However, there are instances where external intervention becomes necessary to support the body’s innate healing mechanism. In this thesis, four such unmet clinical challenges were identified: rapid blood clotting, personalized treatment of burns and chronic wounds, and stretchable implants. Herein, we present novel solutions utilizing silk protein in various formats, each serving a distinct purpose in its respective application. Silk protein (silk fibroin) is being leveraged as a promising biomaterial with potent wound-healing activity. The first experimental chapter describes efforts to develop a potent hemostat for hemorrhage control. The primary goal was to develop a first-aid product for use in a pre-hospital setting where professional healthcare providers are not readily available (such as for battlefield injuries, road accidents, etc.). Herein, a bilayered hemostatic foam was designed such that the top bioactive layer served as a tissue interfacial layer to minimize rebleeding without compromising the clotting abilities. The subsequent two chapters describe strategies for personalized treatment of difficult-to-heal wounds: burns and chronic wounds.
UR  - https://etd.iisc.ac.in/handle/2005/6165
ER  -