Vaishnav, Madhumati Shrikrishna <br/><br/>
Diabetogenesis and albumin molecular modifications newer biological insights and clinical implications 

 - Bangalore  IISc  2022 
 - xxiv, 296p.  col. ill. ;  29.1 cm * 20.5 cm  e-Thesis  16.68Mb 
<br/><br/> includes bibliographic reference and index 
<br/><br/>PhD; 2022; Centre for nano science and engineering 
<br/><br/> To address the many unmet scientific needs in diabetes care (pathogenesis pathways, earliest diagnosis, efficient monitoring, safer and better therapies and importantly prevention approaches), our research focussed on: (a) diabetogenesis and biomarkers and (b) albumin molecular modifications. Establishment of the “Samatvam – Indian Institute of Science” prospective longitudinal cohort, supported by a well annotated biobank repository and a robust cloud based electronic medical record platform, provided the foundation for this translational scientific endeavour. Initially, the "IISc - PathShodh" electrochemistry technology based multianalyte point of care device (POC: anuPath) for selected diabetes biomarkers (HbA1c, hemoglobin, serum albumin, urine albumin and urine creatinine) was validated by simultaneous comparison with “gold standard” conventional laboratory assays. Health worker-based community implementation of this “lab – on – palm”, confirmed its utility both for “in-clinic” diabetes care and “remote” health monitoring. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Diabetes<br/>Albumin<br/>Molecular Modifications<br/>Glycation<br/>Oxidation
<br/><br/><label>Dewey Class. No.: </label>616  / MAD