Ghosh, Biki  <br/><br/>
Enantioselective annulation reactions:  from fischer indolization to de novo arene Construction 

 - Bengaluru :  Indian Institute of science ,  2022. 
 - iv, 256p.  col. ill. ;  29.1cm * 20.5cm  e-Thesis  20.12Mb 
<br/><br/> Includes bibliographical references and index 
<br/><br/>PhD; 2022; Organic chemistry 
<br/><br/> In summary, we have developed the first decarboxylative [4+2]-annulation of ethynyl benzoxazinanones with azlactones for the enantioselective synthesis of cyclic α-quaternary α-acylaminoamides.25 This direct and modular approach combines dipolar copper-allenylidene intermediates and enolates generated from azlactones under bifunctional tertiary aminourea catalysis in a cooperative fashion. The resulting 3,4-dihydroquinolin-2-ones 3.43, bearing vicinal tertiary and quaternary stereogenic centers , are formed as a single diastereomer with good to excellent enantioselectivity. The products are densely functionalized and the synthetic versatility of the terminal alkyne group is demonstrated through a number of synthetic elaborations. This reaction represents the first direct catalytic enantioselective route to cyclic α-quaternary α-acylaminoamides 
<br/><br/><label>Subjects--Topical Terms: </label><br/>annulation reactions<br/>Enantioselective Catalysis<br/>ethynyl benzoxazinanones
<br/><br/><label>Dewey Class. No.: </label>547  / GHO