An Exploration of Molecular Recognition Mechanisms and Ligand Induced Transitions in Biomolecules (Record no. 431631)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 01938nam a22002177a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240322b |||||||| |||| 00| 0 eng d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572 |
| Item number | SIN |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Singh, Kushal |
| 245 ## - TITLE STATEMENT | |
| Title | An Exploration of Molecular Recognition Mechanisms and Ligand Induced Transitions in Biomolecules |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | Bangalore: |
| Name of publisher, distributor, etc | Indian Institute of Science, |
| Date of publication, distribution, etc | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xiv, 252p.: |
| Other physical details | col. ill. |
| Accompanying material | e-Thesis |
| Size of unit | 28.97Mb |
| 500 ## - GENERAL NOTE | |
| General note | Includes bibliographical references |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | PhD;2023;Solid State and Structural Chemistry Unit |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Molecular recognition refers to processes through which biological macromolecules interact with each other or other small molecules through noncovalent interactions to form specific complexes. Applying molecular recognition principles can aid in developing new drugs, particularly new antimicrobial drugs. Drug development also requires considering the effects of physicochemical factors ( ionic environment, temperature, pressure, co-solvents, and pH) on biomolecular folding and cognate ligand binding mechanisms. Therefore, a detailed understanding of the target–ligand interactions is central to understanding biology at the molecular level. In this thesis, using molecular dynamics simulations, I will be discussing the molecular mechanisms by which non-coding RNA molecules (riboswitches) sense their cognate ligands. I will also be discussing the role of biomolecular excited states on the ligand binding mechanisms of riboswitches. Furthermore, I will discuss the role of physico-chemical factors, namely pH, on the binding kinetics of a target-ligand complex. Finally, I will discuss how mutations in biomolecules can be used to trigger the same response generated by ligand binding. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Proteins |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Riboswitches |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Ligand Binding |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Adivesd by Reddy, Govardhan |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | https://etd.iisc.ac.in/handle/2005/6451 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
No items available.
